A relation between longevity, metabolic rate, and activity in shaker mutants of Drosophila melanogaster
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Cited by (69)
Invertebrate model organisms for aging research
2022, Anti-Aging Drug Discovery on the Basis of Hallmarks of AgingCourtship diverges with foraging behaviour in artificially selected populations
2018, Animal BehaviourCitation Excerpt :If this is the case then the differences in courtship seen in this study may be due to differences in underlying physiological processes such as metabolic rate (Biro & Stamps, 2010). Measures of metabolic rate correlate with courtship behaviour in crickets, Gryllodes sigillatus (Ketola & Kotiaho, 2010), activity levels in Drosphila (Trout & Kaplan, 1970) and reproductive success in bank voles, Myodes glareolus (Boratyński & Koteja, 2010). It is also thought to be heritable (Nilsson, ÅKesson, & Nilsson, 2009; Sadowska et al., 2005; although see ; Konarzewski, Książek, & Łapo, 2005).
The redox stress hypothesis of aging
2012, Free Radical Biology and MedicineCitation Excerpt :Nevertheless, despite the differences in life span under flying and nonflying conditions, the total amount of oxygen consumed during life in the two groups remained nearly equal, around 5 ml oxygen/mg body wt [53,62]. The “shaker” mutants of Drosophila are extremely active physically when awake and have shorter life spans than the control flies, but the metabolic potential of the two groups is similar, around 6 ml oxygen/mg body weight [63]. Because longevity varies inversely with the rate of metabolism in poikilotherms, life span alone is an undependable criterion for validating the beneficial effects of experimental treatments on the aging process, unless it is also concurrently demonstrated that fecundity and metabolic potential, which is the product of life span multiplied by the average metabolic rate, have also been elevated.
Energy expenditure and aging
2010, Ageing Research ReviewsCitation Excerpt :The ROL theory is supported by mammalian correlative studies (Cutler, 1982), on manipulation of temperature environments (Atlan et al., 1976; Miquel et al., 1976) and mutant D. melanogaster (shaker mutants that are highly active and sleepless) (Cirelli et al., 2005). The shaker mutants have a reduced lifespan that is inversely proportional to their metabolic rate (Trout and Kaplan, 1970). However, it is refuted by inconsistencies among birds and bats which live several fold longer than do mammals of comparable body size and RMR (Austad and Fischer, 1991).
Drosophila Models of Aging
2006, Handbook of Models for Human AgingFrom Genes to Aging in Drosophila
2003, Advances in GeneticsCitation Excerpt :In house flies, Sohal and colleagues have demonstrated that by housing them under conditions in which they are unable to fly or compete with each other, their life spans will increase to the same amount as with decreases in ambient temperature (Sohal and Buchan, 1981). Conversely, mutations in potassium channel-encoding genes—Shaker and Hyperkinetic—that increase physical activity and metabolic rate result in decreased life span and an increase in the slope of the mortality curve, suggesting that the process of aging has been accelerated (Trout and Kaplan, 1970). The conclusions from these studies are that similar to ambient temperature, physical activity, or more likely metabolic activity, shows an inverse relationship to length of life.