Zinc-containing fiber systems in the cochlear nuclei of the rat and mouse
References (38)
Multipolar cells in the ventrocochlear nucleus project to the dorsal cochlear nucleus and the inferior colliculus
Neurosci. Lett.
(1983)- et al.
Axons from non-cochlear sources in the anteroventral cochlear nucleus of the cat. A study with the rapid golgi method
Neuroscience
(1978) - et al.
Hippocampal zinc, the storage granule pool: localization, physiochemistry, and possible functions
- et al.
A quinoline fluorescence method for visualizing and assaying the histochemically-reactive zinc in the brain
J. Neurosci. Methods
(1987) - et al.
Ultrastructurat characteristics of synaptic endings in the cochlear nucleus having acetylcholinesterase activity
Brain Res.
(1971) - et al.
Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study
Brain Res.
(1985) - et al.
Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide
Brain Res.
(1986) - et al.
Entorhinal and prepyriform cortices of the European hedgehog. A histochemical and densitometric study based on a comparison between Timm's sulphide silver method and the selenium method
Brain Res.
(1985) - et al.
Effects of zinc on markers of glutamate and aspartate neurotransmission in rat hippocampus
Brain Res.
(1985) - et al.
Cholinergic-denervation induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation
Brain Res.
(1984)
Release of endogenous Zn2+ from brain tissue during activity
Nature
Relationship of glutamic acid and zinc to kindling of the rat amygdala: Afferent transmitter systems and excitability in a model of epilepsy
Histochemical demonstration of heavy metals. A revised version of the sulphide silver method suitable for both light and electronmicroscopy
Histochemistry
Exogenous selenium in the brain. A histochemical technique for light and electron microscopical localization of catalytic selenium bonds
Histochemistry
Do the Timm silver-sulphide and the selenium method demonstrate zinc in the brain?
Similarities and differences in the localization of metals in rat brains after treatment with sodium sulphide and sodium selenide
The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS
Histochemistry
Mechanism of action of diabetogenic zinc-chelating agents
Neurobiology of zinc and zinc containing neurons
Int. Rev. Neurobiol.
Cited by (38)
Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :On the other hand, the fact that neurons in the zona incerta and numerous brainstem nuclei are labeled by small intracerebral injections of sodium selenite into the diencephalon (Mengual et al., 2001), and the fact that cells in zona incerta express ZnT3 mRNA (Palmiter et al., 1996), does support the zincergic status of certain populations of neurons in the diencephalon and brain stem. Like the diencephalon, the brainstem and cerebellum contain relatively little vesicular zinc, with the notable exception of the dorsal cochlear nucleus (DCN) in the auditory brainstem (Frederickson et al., 1988), in which the granule neurons send zincergic projections to form the parallel fiber system in the molecular zone. In the midbrain, zinc-positive neurons have been identified in the superior colliculus, periaqueductal gray, precommissural nucleus, nucleus of the posterior commissure, and the deep mesencephalic nucleus, and more caudally they are found in nuclei including the locus coeruleus, the solitary nucleus, and several reticular nuclei (Slomianka et al., 1990; Brown and Dyck, 2004; but see the discussion in the preceding paragraph).
Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission
2015, Neurobiology of DiseaseCitation Excerpt :We studied the role of tonic zinc on DCN fusiform cells. Fusiform cells generate spontaneous action potentials (Rhode et al., 1983; Hancock and Voigt, 2002; Leao et al., 2012) and, because they are embedded in a zinc-rich nucleus (Frederickson et al., 1988; Rubio and Juiz, 1998; Oertel and Young, 2004), they provide an ideal assay for testing the effects of tonic zinc on neuronal excitability. Experiments were conducted according to the methods approved by the Institutional Animal Care and Use Committee of the University of Pittsburgh.
Vestibular evaluation using videonystagmography of chronic zinc deficient patients due to short bowell syndrome
2009, Brazilian Journal of OtorhinolaryngologyCitation Excerpt :The physiological role of the zinc ion in the central nervous system (CNS) is not fully understood. Since the neural pathways in which zinc was found are glutamatergic, and knowing that zinc inhibits the binding of glutamate to its receptors, it is thought that this ion modulates the glutamatergic synapses.1 In 1981, zinc was found in the cochlear nuclei.
Increase in synaptic hippocampal zinc concentration following chronic but not acute zinc treatment in rats
2006, Brain ResearchCitation Excerpt :In the brain, all neurons bearing synaptic zinc are glutamatergic; however, not all glutamatergic neurons contain this metal (Crawford and Connor, 1973; Frederickson and Moncrieff, 1994; Takeda, 2000). Zinc-containing neurons are found primarily in limbic and cerebrocortical systems (Frederickson, 1989; Frederickson and Danscher, 1990; Frederickson et al., 1988). Synaptic zinc plays a modulatory role in synaptic neurotransmission, and the main physiological role of synaptically released zinc is its influence on the brain excitability through modulation of ionic channels and amino acid receptors including AMPA, NMDA and GABA receptors (Bancila et al., 2004; Harrison and Gibbsons, 1994; Smart et al., 1994; Takeda, 2000; Takeda et al., 2003; Zirpel and Parks, 2001).
Immunohistochemical localization of myosin Va in the adult rat brain
2003, Neuroscience