Chronic ultrastructural changes in acoustic trauma: Serial-section reconstruction of stereocilia and cuticular plates
References (23)
- et al.
Variability of noise-induced damage in the guinea pig cochlea: Electrophysiological and morphological correlates after strictly controlled exposures
Hear. Res.
(1983) - et al.
Ultrastructural studies of stereocilia in noise-exposed rabbits
Hear. Res.
(1983) - et al.
Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of tuning curves
Hear. Res.
(1984) - et al.
Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level functions
Hear. Res.
(1984) Effects of acoustic trauma on stereocilia structure and spiral ganglion cell tuning properties in the guinea pig cochlea
Hear. Res.
(1982)Functional significance of dendritic swelling after loud sounds in the guinea pig cochlea
Hear. Res.
(1983)- et al.
Effects of loud tones on the inner ear: A combined electro-physiological and ultrastructural study
Hear. Res.
(1980) - et al.
Immunoelectron microscopic and immunofluorescent localization of cytoskeletal and contractile proteins in inner ear sensory hair cells
Hear. Res.
(1985) - et al.
Changes in the organization of actin filaments in the stereocilia of noise-damaged lizard cochleae
Hear. Res.
(1982) - et al.
Discharge Patterns of Single Fibers in the Cat's Auditory Nerve
(1965)
Auditory-nerve activity in cats with normal and abnormal cochleas
Cited by (100)
The actin cytoskeleton in hair bundle development and hearing loss
2023, Hearing ResearchA comprehensive finite-element human ear model to estimate noise-induced hearing loss associated with occupational noise exposure
2022, Computer Methods and Programs in BiomedicineAge-related stereocilia pathology in the human cochlea
2022, Hearing ResearchCitation Excerpt :There was no evidence of postmortem artifact related to the fusion, loss or disarray that we are capturing here with our algorithm. Another animal study evaluated the effects of hypoxia on cochlear morphology (Shirane and Harrison, 1987) and noted “blebbing” of the apical surface, where a membrane blister forms by extrusion of cytoplasm through the hole in the actin matrix of the cuticular plate where the kinocilium was located during development (Liberman, 1987). We never saw such cytoplasmic blisters, but it is possible that they do not contain myosin 7a or espin and are thus invisible in our confocal images.
Methods for multiscale structural and functional analysis of the mammalian cochlea
2022, Molecular and Cellular NeuroscienceCitation Excerpt :For example, organ of Corti morphology was investigated in excitotoxicity and deafness models or upon aging (Kudo et al., 2003; Mahendrasingam et al., 2011; Puel et al., 1998, 1995) and hair cell and supporting cell structural changes were determined upon developmental maturation or functional impairment in different species, including various rodents and bats (Daudet et al., 1998; Hayashi et al., 2007; Lenoir and Pujol, 1984; Taylor et al., 2012; Vater et al., 1997). On subcellular level, ribbon synapses were investigated to characterize their morphological differences within hair cells (Kantardzhieva et al., 2013), in mutants that lack presynaptic key proteins such as RIBEYE (Jean et al., 2018), otoferlin (Pangrsic et al., 2010; Roux et al., 2006; Vogl et al., 2015), or myosin VI (Roux et al., 2009) as well as upon maturation/aging (Michanski et al., 2019; Sobkowicz et al., 1986) and noise trauma (Liberman, 1987). Next to TEM, scanning electron microscopy (SEM) was found to be an essential tool to investigate whole cochlear structure (Chen et al., 2014; Kaltenbach and Falzarano, 1994).
Mechanisms of Hair Cell Damage and Repair
2019, Trends in NeurosciencesCitation Excerpt :Following the TTS-inducing noise exposure, only minor changes were observed in the stereocilia core, including a shortening of stereocilia rootlets [36]. After PTS-inducing noise trauma, more severe damage was observed in the rootlets, along with stereocilia fusion, and holes in the stereocilia actin matrix [35]. Until recently, stereocilia F-actin cores were thought to turn over through treadmilling within 48–72 h, similar to, although somewhat slower than, filopodia and microvilli [38–40].