ArticleNovel diet consumption and body weight gain are reduced in rats chronically infused with lithium chloride: Mediation by the chemosensitive area postrema
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Patterns of ingestion of rats during chronic oral administration of lithium chloride
2024, Physiology and BehaviorInfection, learning, and memory: Focus on immune activation and aversive conditioning
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The AP is critical in the detection of immune stimulants and nausea-inducing stimuli. AP lesioned rats fail to exhibit conditioned disgust responding in the taste reactivity test when a novel sweet taste is paired with the effects of the toxin LiCl (Eckel and Ossenkopp, 1993, 1996; Ossenkopp and Eckel, 1995). Removal of the AP also results in a failure to exhibit conditioned taste avoidance to LiCl (Ossenkopp and Eckel, 1995) and other nausea-inducing toxins such as deoxynivalenol (vomitoxin, Ossenkopp et al., 1994).
Conditioned disgust in rats (anticipatory nausea) to a context paired with the effects of the toxin LiCl: Influence of sex and the estrous cycle
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :Typically, nausea-inducing toxins, such as LiCl, are used in rodent conditioned disgust paradigms, but rats have also been shown to condition disgust responses with other nausea-inducing treatments, such as rolipram, a phosphodiesterase-4 inhibitor (Rock et al., 2009), fluoxetine and paroxetine, selective serotonin reuptake inhibitors (Limebeer et al., 2009; Tuerke et al., 2009), as well as provocative vestibular stimulation (Cordick et al., 1999; Limebeer et al., 2008; Ossenkopp et al., 2003), a non-pharmacological treatment, and even estradiol injections (Ossenkopp et al., 1996). Although the neural mechanisms underlying conditioned nausea learning require further examination, it does appear that an intact area postrema is critical for successful taste avoidance/aversion learning with LiCl (Eckel and Ossenkopp, 1993, 1996; Ladowsky and Ossenkopp, 1986; Ossenkopp and Eckel, 1994, 1995). The chemosensitive area postrema is a circumventricular medullary structure implicated in the detection of blood-borne toxins, such as LiCl (Borison, 1989).
Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors
2015, Neuroscience LettersCitation Excerpt :However the effect of chronic lithium treatment on food intake is more complex. Some found that chronic lithium treatment had no effect on food intake [3,35], while others found that chronic lithium treatment only reduced novel food consumption but had no effect on familiar food consumption [5,12]. In our study, we found that chronic lithium treatment reversed amphetamine-decreased latency to access and cross bridges, but lithium alone had no effect on latency to access and cross bridges in control rats.
Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning
2012, Physiology and BehaviorThe role of the dura in conditioned taste avoidance induced by cooling the area postrema of male rats
2001, Behavioural Brain ResearchCitation Excerpt :They are also unable to acquire conditioned taste avoidance and taste aversion, that is, a negative palatability shift as measured by display of aversive orofacial responses [8,27,64,74,83]. In permanent lesion studies, damage is often reported in the caudal–medial nucleus of the solitary tract as well as the area postrema [27,70,81,83]. Thus, it is unclear what role the nucleus of the solitary tract plays in the multiple effects of area postrema lesioning.