Hypothalamic circuits and circadian rhythms: Effects of knife cuts vary with their placement within the suprachiasmatic area☆
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Cited by (16)
Biological timekeeping
2012, Sleep Medicine ClinicsCitation Excerpt :When the SCN is surgically isolated from the rest of the hypothalamus in rats, serum corticosterone oscillations continue, whereas locomotor rhythms are lost.154 In addition, surgical cuts to rodent brains between the SCN and PVN abolish reproductive rhythms in hamsters, but rhythmic locomotor activity is maintained in hamsters155,156 and rats.157 These findings provide early evidence for both synaptic coupling of SCN to output tissues, as well as the possibility that humoral signals entrain peripheral tissues.
Lesions of suprachiasmatic nucleus efferents selectively affect rest-activity rhythm
2006, Molecular and Cellular EndocrinologyTemporal and spatial distribution of immunoreactive PER1 and PER2 proteins in the suprachiasmatic nucleus and peri-suprachiasmatic region of the diurnal grass rat (Arvicanthis niloticus)
2006, Brain ResearchCitation Excerpt :In laboratory rats, chemical lesions that destroy cells in the region but spare SCN cells and their axonal projections do not interfere significantly with body temperature rhythms but do interfere with activity rhythms (Lu et al., 2001); this effect could reflect either circadian mechanisms or masking. On the other hand, knife cuts that sever connections between the SCN and LSPV in laboratory rats do not appear to interfere with rhythms (Brown and Nunez, 1986). One potential explanation of this paradox is that a diffusible factor from the SCN may communicate circadian signals to the LSPV.
Effects of damage to SCN neurons and efferent pathways on circadian activity rhythms of hamsters
1993, Brain Research BulletinEffects of aging on the diurnal pattern of water intake in rats
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Portions of these results were presented at the 13th Annual Meeting of the Society for Neuroscience, November 1983, Boston, MA, Abstract 312.15.