ArticleMK801-Induced hyper activity: Duration of effects in rats
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Sex-specific behavioral impairments produced by neonatal exposure to MK-801 are partially reversed by adolescent CDPPB treatment
2022, Neurotoxicology and TeratologyCitation Excerpt :The effects of MK-801 on locomotor activity are well-known. Many studies have observed increased activity following acute treatment of adult rats or mice (Hargreaves and Cain, 1992, 1995; Andine et al., 1999; Zuo et al., 2006) or treatment during the neonatal critical period (Ravandia et al., 2019; Oliveira-Pinto et al., 2015; Akillioglu et al., 2012; Fredriksson and Archer, 2004; Harris et al., 2003). Although the current study did not examine neural mechanisms, others have found that acute administration of MK-801 to adult mice increases glutamate and ascorbic acid levels in the prefrontal cortex (PFC) concurrent with motor activation (Zuo et al., 2006).
Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
2021, Neuroscience LettersCitation Excerpt :Furthermore, MK-801-induces positive, negative and cognitive schizophrenia symptoms in laboratory animals. The systemic application of MK-801 causes hyperactivity in the open field [7,8], inhibition of social interaction [9], anhedonia [10], increased stereotypy [11], cognitive deficits in pre-pulse inhibition of acoustic startle response (PPI) [12] and spatial learning tasks, such as Morris water maze (MWM) [13], Carousel maze (CM) [13–15] or radial maze [16]. We included studies using only acute or sub-chronic MK-801 application for schizophrenia induction in adult rats or mice in the review.
β3-adrenoceptor activation exhibits a dual effect on behaviors and glutamate receptor function in the prefrontal cortex
2021, Behavioural Brain ResearchCitation Excerpt :Consistent with our hypothesis, enhancement of NMDA receptor function is a core strategy for learning and memory [30]. In contrast, a previous behavioral pharmacology study from Hargreaves et al.(1995) reports that NMDA receptor antagonists including ketamine or phencyclidine can cause the formation of psychotic symptoms [31]. The reduction of NMDA receptor-mediated signaling induced by higher dosage of SR58611A (20 mg/kg) may underlie its detrimental effects on recognition memory.
fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation
2017, NeuroImageCitation Excerpt :MK801 reversal of the olfactory adaptations is consistent with the result from a previous report: MK801 blocks the behavioral olfactory adaptation (Chaudhury et al., 2010). Furthermore, the pharmacodynamics of MK801 observed in this study is consistent with the long-lasting effect of MK801-induced behavioral hyperactivity reported in previous studies (Hargreaves and Cain, 1995; Roberts et al., 2008). The olfactory responses during the 4-h experiment session of the MK801 reversal study can be divided into three conditions: 1) naïve condition (the response to the first stimulation); 2) adapted response (the olfactory responses during ~30 min to 2 h in which the adaptation to repeated stimulations has been developed); and 3) response after MK801 injection.
Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors
2014, Biological PsychiatryCitation Excerpt :Given that children with ADHD exhibit prefrontal hypoactivity (15,16), the elevated NMDAR function by low-dose MPH might underlie its beneficial effects on memory, attention, and other cognitive aspects. However, because NMDAR antagonists, such as phencyclidine or ketamine, can lead to the formation of psychotic symptoms, including hyperlocomotion (32,47), the reduced glutamate signaling by high-dose MPH might underlie its psychosis-inducing effects. It is known that MPH acts as a NET and DAT inhibitor, and our data indicate that low-dose MPH potentiates NMDAR functions mainly through the norepinephrine system.
Memantine is a useful drug to prevent the spatial and non-spatial memory deficits induced by methamphetamine in rats
2010, Pharmacological Research