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Rivastigmine does not alter cocaine-induced subjective effects or self-administration
2019, Pharmacology Biochemistry and BehaviorCitation Excerpt :This hyper-cholinergic state of reduced motivation has been correlated with reduced drug-seeking behavior and reduced rewarding effects of substances. For example, rhesus monkeys given the acetylcholinesterase-inhibitor (AChEi) physostigmine exhibit decreased cocaine self-administration (de la Garza and Johanson, 1982). In rat lines, Grasing et al. (2011) observed decreased self-administration of cocaine during active treatment with AChEis rivastigmine and donepezil, with persistent decreases noted after discontinuation of donepezil but not rivastigmine.
A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders
2016, Behavioural Brain ResearchCitation Excerpt :An early study found that pretreatment with single doses of the cholinesterase inhibitor physostigmine (0.1–0.5 mg/kg) decreased cocaine self-administration in rhesus monkeys under FR-1 and caused vomiting and diarrhea [129], consistent with its administration at relatively high dose causing reward inhibition. When either cocaine or procaine were self-administered by rhesus monkeys under FR-10, 0.02–0.05 mg/kg doses of physostigmine increased responding in 3 of 10 sessions, with declines uniformly observed following greater physostigmine doses [175]. This inverted “U” dose-response relationship is again consistent with reward enhancement and inhibition, respectively.
Cholinergic modulation of food and drug satiety and withdrawal
2012, Physiology and BehaviorCitation Excerpt :Different lines of research suggest a fundamental role for accumbens cholinergic interneurons in drug reward. Systemic injection of acetylcholinesterase inhibitors, which serve as indirect ACh agonists by inhibiting ACh enzymatic degradation, can decrease cocaine self-administration in monkeys [36], block heroin seeking [37], and prevent cocaine and heroin conditioned place preference in rats [38], as well as preference for cocaine in mice [39]. Other studies have assessed the specific role of cholinergic interneurons in the NAc in the development of cocaine conditioning.
Involvement of cholinergic neuronal systems in intravenous cocaine self-administration
2004, Neuroscience and Biobehavioral ReviewsDrug abuse and bipolar disorder: Comorbidity or misdiagnosis?
2001, Journal of Affective DisordersCocaine induces conditioned place preference and increases locomotor activity in male Japanese quail
2001, Pharmacology Biochemistry and Behavior