Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning
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Glutamate receptors and synaptic plasticity: The impact of Evans and Watkins
2022, NeuropharmacologyCitation Excerpt :These observations suggest that MCPG-sensitive mGluRs act as co-triggers with NMDARs in the induction of LTP. MCPG was also found to inhibit the induction of LTP at the perforant path synapse in vivo (Riedel and Reymann, 1993; Richter-Levin et al., 1994). We also found that MCPG inhibited the induction of AP5-insensitive, mossy fibre LTP (Bashir et al., 1993), suggesting that mGluRs can also function as co-triggers with kainate receptors in the induction of LTP.
The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats
2015, NeuroscienceCitation Excerpt :Glutamatergic neurotransmission is known to play an important role in the course of hippocampal modulation of learning and memory processes, long-term potentiation (LTP) and synaptic plasticity (Harris et al., 1984; Bashir et al., 1993; Jamali-Raeufy et al., 2011; Khakpai et al., 2012). NMDA receptors are among the glutamatergic subtype receptors, widely distributed in the mammalian CNS with high densities in cerebral cortex superficial layers like the CA1 region of the hippocampus (Morris, 1989; Richter-Levin et al., 1994; Davis and Linn, 2003). Besides, compelling evidence has confirmed the essential involvement of the hippocampus upon memory processes in animals and humans (Squire, 1992; Braak and Braak, 1993; Alvarez and Banzan, 1999).
Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats
2013, Behavioural Brain ResearchCitation Excerpt :Keller et al. [31] reported a correlation between the hippocampal N-methyl-d-aspartate (NMDA) receptors density and the learning ability in avoidance task response in rats. NMDA receptors are among the glutamatergic subtype receptors, widely distributed in the mammalian CNS with high densities mainly in cerebral cortex superficial layers including the CA1 region and dentate gyrus of the hippocampus [32–37]. These receptors play an important role in an array of cognitive performances.
The role of intracellular calcium stores in synaptic plasticity and memory consolidation
2013, Neuroscience and Biobehavioral ReviewsRole of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning
2013, NeuropharmacologyCitation Excerpt :Co-application of an mGlu5 antagonist with an antagonist of group II mGlu receptors prevents object recognition memory using mechanisms that also involve the perirhinal cortex (Barker et al., 2006). Possible joint effects of these receptors were described using first generation mGlu antagonists, such as MCPG (α-methyl-4-carboxyphenylglycine), where impairments of spatial alternation performance (Riedel et al. 199b) and spatial learning in the water maze were reported (Richter-Levin et al., 1994; Bordi et al., 1996). Application of an mGlu5 PAM, 2-methyl-6- (phenylethynyl) pyridine (MPEP), prevents object-place learning (Popkirov and Manahan-Vaughan, 2011).