Short communicationNMDA receptor blockade in the periaqueductal grey prevents stress-induced analgesia in attacked mice
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Cited by (39)
The periaqueductal gray and control of bladder function
2023, Neuro-Urology Research: A Comprehensive OverviewMu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception
2020, Pharmacology Biochemistry and BehaviorVentrolateral Periaqueductal Gray Matter Neurochemical Lesion Facilitates Epileptogenesis and Enhances Pain Sensitivity in Epileptic Rats
2019, NeuroscienceCitation Excerpt :Early studies have shown that microinjection of glutamate receptor agonists or gamma-aminobutyric acid (GABA) antagonists into the vlPAG produces antinociceptive effect (Moreau and Fields, 1986; Ness and Gebhart, 1987; Carstens et al., 1988; Jones and Gebhart, 1988; Sandkuhler et al., 1989; Carstens et al., 1990; Budai and Fields, 1998; Morgan et al., 2003). In contrast, microinjection of glutamate receptor antagonists or GABA agonists into the vlPAG produces hyperalgesia (Moreau and Fields, 1986; Depaulis et al., 1987; Siegfried and de Souza, 1989; Behbehani et al., 1990). Anti-migraine medicine sumatriptan inhibited GABAergic transmission via activation of 5-HT1 receptor, and GABAergic transmission was inhibited by other selective 5-HT1A, 5-HT1B and 5-HT1D agonists (Jeong et al., 2008).
Repetitive transcranial magnetic stimulation in chronic pain: A review of the literature
2015, Archives of Physical Medicine and RehabilitationCitation Excerpt :The PAG has limited direct projections to the spinal cord and modulates nociceptive inputs through its connections with the rostral ventral medulla, which in turn projects to the dorsal horn of the spinal cord as part of the descending pain modulation system.78 Glutamate and specific N-methyl-D-aspartate (NMDA) receptor ligands produce analgesia when applied to the ventrolateral PAG.79,80 Therefore, both the activation of the PAG via glutamate/NMDA agonists and the disinhibition produced by GABA blockade/opioid receptors activation may lead to antinociceptive modulation of spinal pain inputs.
Open elevated plus maze-induced antinociception in rats: A non-opioid type of pain inhibition?
2009, Physiology and Behavior