Research reportThe role of dendritic diameters in maximizing the effectiveness of synaptic inputs
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Phosphatidylinositol (3,5)-bisphosphate machinery regulates neurite thickness through neuron-specific endosomal protein NSG1/NEEP21
2023, Journal of Biological ChemistryCell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex
2022, NeuronCitation Excerpt :Notably, we found integration characteristics of various model configurations to be dependent on the synaptic conductance targeting each dendritic section (Figures S8A–S8F). As predicted by the work of others (Branco and Häusser, 2011; Holmes, 1989; Polsky et al., 2004; Tran-Van-Minh et al., 2016), dendrite diameter also played a critical role, with thinner dendrites producing stronger nonlinearities (Figures S8G–S8J). We found the location of inhibition to have a lesser effect on multimodal enhancement in our models.
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome
2020, Cell ReportsCitation Excerpt :Cytoplasmic resistance (Ri) was set to 150 Ω.cm, membrane capacitance (CM) was set to 1 μF/cm2 and membrane resistance (RM) was set to 30 MΩ.cm2. The electrical impact of dendritic spines in realistic neuron morphologies was simulated by doubling dendritic CM and halving dendritic RM (Holmes, 1989). The axon consisted of a variable length axon initial segment (AIS) followed by twenty 100 μm long segments with low membrane capacitance (CM = 0.1 μF/cm2) and high resistance (RM = 150 kΩ.cm2) representing myelinated regions, interspersed with 1 μm long Nodes of Ranvier (RM = 50 Ω.cm2).
Neural Morphology and Addiction
2018, Neural Mechanisms of AddictionA Cooperative Switch Determines the Sign of Synaptic Plasticity in Distal Dendrites of Neocortical Pyramidal Neurons
2006, NeuronCitation Excerpt :Passive parameters were Cm = 1 μF/cm2, Rm = 50 kΩcm2, with Vrest = −70 mV. Spines were accounted for by scaling dendritic membrane capacitance and conductances by a factor of two (Holmes, 1989; Shelton, 1985). Synapses were placed at a range of dendritic locations and consisted of identical AMPA conductances with Erev = 0 mV, gmax = 1 nS, τrise = 0.2 ms, and τdecay = 1.7 ms (Häusser and Roth, 1997).