Invited paperDihydrolipoamide dehydrogenase: Functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases
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Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer's disease
2021, Genes and DiseasesCitation Excerpt :Moreover, dld-1 suppression also improved the acetylcholine neurotransmission in human tau model of Alzheimer's disease.25 The DLD enzyme is a subunit of three ketoacid dehydrogenase complexes, each of which contributes to energy metabolism, pyruvate dehydrogenase complex PDH, α-ketoglutarate dehydrogenase complex (KGDH) and branched chain ketoacid dehydrogenase complex (BCKDH).26,27 Reduced levels of these enzymes in post-mortem brain tissues and fibroblasts of patients with either Alzheimer's or Parkinson's disease indicate a direct link between energy metabolism and AD.28–33
Energy metabolism: 2-0xoglutarate dehydrogenase complex
2021, Encyclopedia of Biological Chemistry: Third EditionA multipronged approach unravels unprecedented protein–protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex
2018, Journal of Biological ChemistryCitation Excerpt :The titration plots did not exhibit saturation (Fig. S3), more probably due to a weak and transient binding between components (34). According to the accepted OGDHc mechanism, with each turnover, the reduced lipoyl domain (dihydrolipoamide) on hE2o must be re-oxidized by the FAD on hE3 (45, 46). The exact stoichiometry of the assembly of the hE1o, hE2o, and hE3 components into hOGDHc is unknown.
Genotype-dependent regulation of drought-responsive genes in tolerant and sensitive sugarcane cultivars
2017, GeneCitation Excerpt :All these unitags showed induction by the tolerant bulk and n.s. by the sensitive bulk (Table S3, Fig. S3), reinforcing the glycolysis accentuation, after 24 h of irrigation suppression, in the tolerance response and the selection of some components for RT-qPCR gene expression validation. Dihydrolipoyl dehydrogenase (LDP) is a crucial component of the tricarboxylic acid (TCA) cycle which is an important aerobic pathway for the carbohydrates and fatty acids oxidations, catalyzing the electron transfer between pyridine nucleotides and disulfide compounds (Carothers et al., 1989). The LPD gene (unitag SD86754; FCTol = 5.93, FCSens = − 1.38) presented induction by the tolerant cultivar CTC15 (1.74 fold) in the RT-qPCR assay (Table 2, Fig. 1I).
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Postdoctoral Fellow supported by Fulbright-Ministerio de Educacion y Ciencia grant.