Abstract
Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.
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Acknowledgments
We thank Prof. Y. Shen and Mr. D. Huang for technical assistance and Dr. S. R. Wang for critical comments on the manuscript. This study was supported by grants from the Grants for Scientific Research of BSKY (XJ2005006) from Anhui Medical University, the Excellent Talent of Anhui province of China (06043090), the National Century Excellent Talents in University of China (NCET-06-0557) to L. Wang, and Natural Science Foundation of Anhui Province Department of Education (NSFA KJ2007A028) to D. Kong.
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The authors Z. Wu and Q. Xu contributed equally to this work.
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Wu, Z., Xu, Q., Zhang, L. et al. Protective Effect of Resveratrol against Kainate-induced Temporal Lobe Epilepsy in Rats. Neurochem Res 34, 1393–1400 (2009). https://doi.org/10.1007/s11064-009-9920-0
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DOI: https://doi.org/10.1007/s11064-009-9920-0