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Lateral dendritic shunt inhibition can regularize mitral cell spike patterning

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Abstract

Mitral cells, the principal output neurons of the olfactory bulb, receive direct synaptic activation from primary sensory neurons. Shunting inhibitory inputs delivered by granule cell interneurons onto mitral cell lateral dendrites, while poorly positioned to prevent spike initiation, are believed to influence spike timing and underlie coordinated field potential oscillations. We investigated this phenomenon in a reduced compartmental mitral cell model suitable for incorporation into network simulations. Lateral dendritic shunt conductances delayed spiking to a degree dependent on both their electrotonic distance and phase of onset. Moreover, when the afferent activation of mitral cells was loosely coordinated in time, recurrent inhibition significantly narrowed the distribution of mitral cell spike times, illustrating a tendency towards coordinated synchronous activity. However, if mitral cell activity was initially disorganized, recurrent inhibition actually increased the variance in spike timing. This result suggests an essential role for early mechanisms of temporal coordination in olfaction, such as sniffing and the initial synchronization of mitral cell intrinsic oscillations by periglomerular cell-mediated inhibition.

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Authors and Affiliations

  1. Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, 14853, USA

    François David & Christiane Linster

  2. Neurosciences Sensorielles Comportement Cognition, CNRS-Université Claude Bernard Lyon 1, 50, Avenue Tony Garnier, 69366, Lyon Cedex 07, France

    François David

  3. Department of Psychology, Cornell University, Ithaca, NY, 14853, USA

    Thomas A. Cleland

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  1. François David
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  2. Christiane Linster
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  3. Thomas A. Cleland
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Correspondence to François David.

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Action Editor: James M. Bower

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David, F., Linster, C. & Cleland, T.A. Lateral dendritic shunt inhibition can regularize mitral cell spike patterning. J Comput Neurosci 25, 25–38 (2008). https://doi.org/10.1007/s10827-007-0063-5

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  • DOI: https://doi.org/10.1007/s10827-007-0063-5

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