Skip to main content
SpringerLink
Log in

TRP Channels as Mediators of Oxidative Stress

  • Chapter
  • First Online:
Book cover Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

The transient receptor potential (TRP) protein superfamily is a diverse group of cation-permeable channels expressed in mammalian cells, which is divided into six subfamilies based on sequence identity. Three subfamilies have members with roles in oxidative stress: the TRPC subfamily characterized by receptor operated calcium entry channels; the TRPM subfamily with a number of members involved in cell proliferation and death; and the TRPV subfamily which is activated by chemical, mechanical, and physical stimuli. The TRPC members TRPC3 and TRPC4 can serve as subunits of a redox-sensitive ion channel in native aortic endothelial cells. The TRPM family member TRPM2 has a number of physiologic isoforms expressed in many cell types and responds to stimuli including oxidative stress, TNFα, and β-amyloid peptide. The important role of TRPM2 isoforms in cell proliferation and oxidant-induced cell death has been well established using divergent cell systems and techniques including overexpression, channel depletion or inhibition, and calcium chelation. TRPM7 has been shown to be involved in Ca2+ influx and anoxic cell death in cortical neurons. In these cells and in B cells, precise expression of TRPM7 is necessary for cell survival. TRPV1 is involved in oxidant stress-induced pain and in neuronal injury, contributing to diabetic sensory neuropathy. Future studies will likely identify additional channels involved in oxidant injury, as well as better define mechanisms through which these channels are regulated and mediate their effects. Therapeutic approaches to modulate activation of specific TRP channels are likely to have an important impact in reducing tissue damage in a number of diseases resulting from oxidant stress including ischemia/reperfusion injury and diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517–524

    Article  CAS  PubMed  Google Scholar 

  2. Birnbaumer L (2009) The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. Annu Rev Pharmacol Toxicol 49:395–426

    Article  CAS  PubMed  Google Scholar 

  3. Montell C (2005) The TRP superfamily of cation channels. Sci STKE 2005:re3

    PubMed  Google Scholar 

  4. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387–417

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165–217

    Article  CAS  PubMed  Google Scholar 

  6. Voets T, Owsianik G, Janssens A, Talavera K, Nilius B (2007) TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol 3:174–182

    Article  CAS  PubMed  Google Scholar 

  7. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, Wissenbach U, Flockerzi V (2003) Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem 278:30813–30820

    Article  CAS  PubMed  Google Scholar 

  8. Watanabe H, Murakami M, Ohba T, Takahashi Y, Ito H (2008) TRP channel and cardiovascular disease. Pharmacol Ther 118:337–351

    Article  CAS  PubMed  Google Scholar 

  9. Langley B, Ratan RR (2004) Oxidative stress-induced death in the nervous system: cell cycle dependent or independent? J Neurosci Res 77:621–629

    Article  CAS  PubMed  Google Scholar 

  10. Waring P (2005) Redox active calcium ion channels and cell death. Arch Biochem Biophys 434:33–42

    Article  CAS  PubMed  Google Scholar 

  11. Chandra J, Samali A, Orrenius S (2000) Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29:323–333

    Article  CAS  PubMed  Google Scholar 

  12. Gopalakrishna R, Jaken S (2000) Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28:1349–1361

    Article  CAS  PubMed  Google Scholar 

  13. Miller BA (2006) The role of TRP channels in oxidative stress-induced cell death. J Membr Biol 209:31–41

    Article  CAS  PubMed  Google Scholar 

  14. Crompton M (1999) The mitochondrial permeability transition pore and its role in cell death. Biochem J 341(Pt 2):233–249

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Duchen MR, Verkhratsky A, Muallem S (2008) Mitochondria and calcium in health and disease. Cell Calcium 44:1–5

    Article  CAS  PubMed  Google Scholar 

  16. Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626–629

    Article  CAS  PubMed  Google Scholar 

  17. Agam K, von Campenhausen M, Levy S, Ben-Ami HC, Cook B, Kirschfeld K, Minke B (2000) Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo. J Neurosci 20:5748–5755

    CAS  PubMed  Google Scholar 

  18. Yoon J, Ben-Ami HC, Hong YS, Park S, Strong LL, Bowman J, Geng C, Baek K, Minke B, Pak WL (2000) Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila. J Neurosci 20:649–659

    CAS  PubMed  Google Scholar 

  19. Vazquez G, Wedel BJ, Trebak M, Bird StJG, Putney JW, Jr. (2003) Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. J Biol Chem 278:21649–21654

    Article  CAS  PubMed  Google Scholar 

  20. van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, Snyder SH (2005) Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature 434:99–104

    Article  PubMed  Google Scholar 

  21. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709–720

    Article  CAS  PubMed  Google Scholar 

  22. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645–655

    Article  CAS  PubMed  Google Scholar 

  23. Goel M, Sinkins WG, Schilling WP (2002) Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 277:48303–48310

    Article  CAS  PubMed  Google Scholar 

  24. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99: 7461–7466

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2003) Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 278:39014– 39019

    Article  PubMed  Google Scholar 

  26. Liu X, Bandyopadhyay BC, Singh BB, Groschner K, Ambudkar IS (2005) Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3. J Biol Chem 280:21600–21606

    Article  CAS  PubMed  Google Scholar 

  27. Balzer M, Lintschinger B, Groschner K (1999) Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res 42:543–549

    Article  CAS  PubMed  Google Scholar 

  28. Poteser M, Graziani A, Rosker C, Eder P, Derler I, Kahr H, Zhu MX, Romanin C, Groschner K (2006) TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem 281:13588–13595

    Article  CAS  PubMed  Google Scholar 

  29. Yao X, Garland CJ (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 97:853–863

    Article  CAS  PubMed  Google Scholar 

  30. Groschner K, Rosker C, Lukas M (2004) Role of TRP channels in oxidative stress. Novartis Found Symp 258:222–230, discussion 231–225, 263–226

    Article  CAS  PubMed  Google Scholar 

  31. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori Y (2006) Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2:596–607

    Article  CAS  PubMed  Google Scholar 

  32. Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515–1520

    CAS  PubMed  Google Scholar 

  33. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163–173

    Article  CAS  PubMed  Google Scholar 

  34. Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA (2003) A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem 278:16222–16229

    Article  CAS  PubMed  Google Scholar 

  35. Prawitt D, Enklaar T, Klemm G, Gartner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (2000) Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum Mol Genet 9:203–216

    Article  CAS  PubMed  Google Scholar 

  36. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863–877

    Article  CAS  PubMed  Google Scholar 

  37. Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769

    CAS  PubMed  Google Scholar 

  38. Schmitz C, Perraud AL (2005) The TRPM cation channels in the immune context. Curr Pharm Des 11:2765–2778

    Article  CAS  PubMed  Google Scholar 

  39. Xu XZ, Moebius F, Gill DL, Montell C (2001) Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci USA 98:10692–10697

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Perraud AL, Schmitz C, Scharenberg AM (2003) TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium 33:519–531

    Article  CAS  PubMed  Google Scholar 

  41. Orfanelli U, Wenke AK, Doglioni C, Russo V, Bosserhoff AK, Lavorgna G (2008) Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res 18:1128–1140

    Article  CAS  PubMed  Google Scholar 

  42. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411:595–599

    Article  CAS  PubMed  Google Scholar 

  43. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, Furuichi K (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science 293:1327–1330

    Article  CAS  PubMed  Google Scholar 

  44. Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, Shimizu N (1998) Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124–131

    Article  CAS  PubMed  Google Scholar 

  45. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. Embo J 25:1804–1815

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Fonfria E, Marshall IC, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD, McNulty S (2005) Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 95:715–723

    Article  CAS  PubMed  Google Scholar 

  47. Wehage E, Eisfeld J, Heiner I, Jungling E, Zitt C, Luckhoff A (2002) Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 277:23150–23156

    Article  CAS  PubMed  Google Scholar 

  48. Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Kruger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH (2006) Activation of T cell calcium influx by the second messenger adp-ribose. J Biol Chem 281:2489–2496

    Article  CAS  PubMed  Google Scholar 

  49. Yang XR, Lin MJ, McIntosh LS, Sham JS (2006) Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. Am J Physiol Lung Cell Mol Physiol 290:L1267–L1276

    Article  CAS  PubMed  Google Scholar 

  50. Wilkinson JA, Scragg JL, Boyle JP, Nilius B, Peers C, H2 O (2008) 2-stimulated Ca2+ influx via TRPM2 is not the sole determinant of subsequent cell death. Pflugers Arch 455: 1141–1151

    Google Scholar 

  51. Kolisek M, Beck A, Fleig A, Penner R (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 18:61–69

    Article  CAS  PubMed  Google Scholar 

  52. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM (2005) Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem 280:6138–6148

    Article  CAS  PubMed  Google Scholar 

  53. Fonfria E, Marshall ICB, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, Scharenberg AM, McNulty S (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly (ADP-Ribose) polymerase. Br J Pharmacol 143: 186–192

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  54. Buelow B, Song Y, Scharenberg AM, Poly T (2008) (ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem 283:24571–24583

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  55. Kuhn FJ, Heiner I, Luckhoff A (2005) TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose. Pflugers Arch 451:212–219

    Article  PubMed  Google Scholar 

  56. Kuhn FJ, Luckhoff A (2004) Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. J Biol Chem 279:46431–46437

    Article  PubMed  Google Scholar 

  57. McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278:11002–11006

    Article  CAS  PubMed  Google Scholar 

  58. Du J, Xie J, Yue L (2009) Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci USA 106:7239–7244

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  59. Tong Q, Zhang W, Conrad K, Mostoller K, Cheung JY, Peterson BZ, Miller BA (2006) Regulation of the TRP Channel TRPM2 by the Ca2+ sensor Calmodulin. J Biol Chem 281:9076–9085

    Article  CAS  PubMed  Google Scholar 

  60. McNulty S, Fonfria E (2005) The role of TRPM channels in cell death. Pflugers Arch 451:235–242

    Article  CAS  PubMed  Google Scholar 

  61. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume T, Katsuki H, Mori Y, Akaike A (2006) A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci 101:66–76

    Article  CAS  PubMed  Google Scholar 

  62. Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA (2006) TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol 290:C1146–C1159

    Article  CAS  PubMed  Google Scholar 

  63. Ma S, Ochi H, Cui L, Zhang J, He W (2003) Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site alpha-specific nuclear factor binding activity and the activation of caspase-3. Exp Gerontol 38:1109– 1118

    Article  CAS  PubMed  Google Scholar 

  64. Denning TL, Takaishi H, Crowe SE, Boldogh I, Jevnikar A, Ernst PB (2002) Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radic Biol Med 33:1641–1650

    Article  CAS  PubMed  Google Scholar 

  65. Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431–1568

    CAS  PubMed  Google Scholar 

  66. Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, Heizer JW, Schmitz C, Mocz G, Garruto RM, Perraud AL (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci USA 105:18029–18034

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  67. Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ, Wu ML (2006) Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ 13:1815–1826

    Article  CAS  PubMed  Google Scholar 

  68. Hecquet CM, Ahmmed GU, Vogel SM, Malik AB (2008) Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. Circ Res 102:347–355

    Article  CAS  PubMed  Google Scholar 

  69. Hecquet CM, Malik AB (2009) Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb Haemost 101:619–625

    PubMed Central  CAS  PubMed  Google Scholar 

  70. Schuber F, Lund FE (2004) Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites. Curr Mol Med 4:249–261

    Article  CAS  PubMed  Google Scholar 

  71. Massullo P, Sumoza-Toledo A, Bhagat H, Partida-Sanchez S (2006) TRPM channels, calcium and redox sensors during innate immune responses. Semin Cell Dev Biol 17:654–666

    Article  CAS  PubMed  Google Scholar 

  72. Beck A, Kolisek M, Bagley LA, Fleig A, Penner R (2006) Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. Faseb J 20:962–964

    Article  CAS  PubMed  Google Scholar 

  73. Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R (2009) TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal 2:ra23

    Article  PubMed Central  PubMed  Google Scholar 

  74. Nadler MJ, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes AJ, Kurosaki T, Kinet JP, Penner R, Scharenberg AM, Fleig A (2001) LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature 411:590–595

    Article  CAS  PubMed  Google Scholar 

  75. Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043–1047

    Article  CAS  PubMed  Google Scholar 

  76. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31:166–170

    Article  CAS  PubMed  Google Scholar 

  77. Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM (2003) Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell 114:191–200

    Article  CAS  PubMed  Google Scholar 

  78. He Y, Yao G, Savoia C, Touyz RM (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circ Res 96:207–215

    Article  CAS  PubMed  Google Scholar 

  79. Hanano T, Hara Y, Shi J, Morita H, Umebayashi C, Mori E, Sumimoto H, Ito Y, Mori Y, Inoue R (2004) Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci 95:403–419

    Article  CAS  PubMed  Google Scholar 

  80. Song Y, Hsu YH, Niu T, Manson JE, Buring JE, Liu S (2009) Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. BMC Med Genet 10:4

    Article  PubMed Central  PubMed  Google Scholar 

  81. Romero JR, Ridker PM, Zee RY (2009) Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. Stroke 40:2965–2968

    Article  PubMed Central  PubMed  Google Scholar 

  82. Shin CY, Shin J, Kim BM, Wang MH, Jang JH, Surh YJ, Oh U (2003) Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons. Mol Cell Neurosci 24:57–68

    Article  CAS  PubMed  Google Scholar 

  83. Kim SR, Lee DY, Chung ES, Oh UT, Kim SU, Jin BK (2005) Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. J Neurosci 25:662–671

    Article  CAS  PubMed  Google Scholar 

  84. Chuang HH, Lin S (2009) Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci USA 106:20097–20102

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  85. Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM (2006) TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell 127:1123–1135

    Article  CAS  PubMed  Google Scholar 

  86. Hong S, Agresta L, Guo C, Wiley JW (2008) The TRPV1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy. J Neurochem 105:1212–1222

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pediatrics and Biochemistry and Molecular Biology, Milton S. Hershey Medical Center, Penn State Hershey Children’s Hospital, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA

    Barbara A. Miller

  2. Departments of Pediatrics, Milton S. Hershey Medical Center, Penn State Hershey Children’s Hospital, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA

    Wenyi Zhang

Authors
  1. Barbara A. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wenyi Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Barbara A. Miller .

Editor information

Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Miller, B.A., Zhang, W. (2011). TRP Channels as Mediators of Oxidative Stress. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_29

Download citation

Publish with us

Policies and ethics

Search

Navigation