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Behavioral Neurobiology of Schizophrenia and Its Treatment pp 485–508Cite as

Prefrontal Cortical Circuits in Schizophrenia

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 4))

Abstract

Impaired cognitive functioning, including deficits in working memory, is considered to be a core and disabling feature of schizophrenia that is difficult to treat. Deficits in working memory in schizophrenia are attributable, at least in part, to specific pathological alterations in the neuronal circuitry of the dorsolateral prefrontal cortex that involve, but are not restricted to, disturbances in glutamate, GABA, and dopamine neurotransmission. Cannabis use provides an example of an environmental exposure that may have a deleterious impact on these neurotransmitter systems and thereby contribute to worsening of cognitive functioning in schizophrenia. Increasing knowledge of the nature of the molecular alterations in these cortical circuits may lead to the development of new pathophysiologically informed treatment options for cognitive deficits in schizophrenia.

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Acknowledgments

Cited work conducted by the authors was supported by NIH grants MH043784, MH045156, and MH084053 from the National Institute of Mental Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. The authors thank Mary Brady for preparation of the figures and Lindsay Karr for preparation of the manuscript.

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  1. Department of Psychiatry, University of Pittsburgh, 3811 O’Hara Street, BST W1653, Pittsburgh, PA, 15213, USA

    David W. Volk & David A. Lewis

  2. Department of Neuroscience, University of Pittsburgh, 3811 O’Hara Street, BST W1653, Pittsburgh, PA, 15213, USA

    David A. Lewis

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  1. , Dept. of Psychiatry - MC 0804, University of San Diego, Gilman Drive 9500, La Jolla, 92093, USA

    Neal R. Swerdlow

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Volk, D.W., Lewis, D.A. (2010). Prefrontal Cortical Circuits in Schizophrenia. In: Swerdlow, N. (eds) Behavioral Neurobiology of Schizophrenia and Its Treatment. Current Topics in Behavioral Neurosciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_44

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