Regular ArticleFetal Alcohol-Exposed Rats Exhibit Differential Response to Cholinergic Drugs on a Delay-Dependent Memory Task☆,☆☆
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Cited by (26)
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics
2015, Physiology and BehaviorCitation Excerpt :Contextual fear conditioning, another hippocampus dependent task, can be especially compromised by neonatal ethanol exposure, even though learning about a concomitant conditioned stimulus (CS) is unaffected [23,63,64]. Another consistent finding is an ethanol impairment in short-term or working memory processes, which has been tested in several paradigms [21,25,65,66]. For the past 15 years, our laboratory has been working to better characterize ethanol-induced deficits in various aspects of short-term memory.
Neonatal alcohol exposure impairs contextual fear conditioning in juvenile rats by disrupting cholinergic function
2013, Behavioural Brain ResearchDeficits in trace fear conditioning in a rat model of fetal alcohol exposure: dose-response and timing effects
2009, AlcoholCitation Excerpt :For the most part, these studies have assessed spatial memory processes using tasks, such as the Morris water maze, radial arm maze, and T-maze alternation. Altered spatial memory performance has been observed in both young and adult rats following neonatal ethanol exposure (e.g., Goodlett and Johnson, 1997; Nagahara and Handa, 1999; Reyes et al., 1989; Thomas et al., 2000). There are sparse reports of the consequences of alcohol exposure on hippocampal-dependent nonspatial memory performance (but see Green et al., 1992).
Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats
2009, Neurotoxicology and TeratologyCitation Excerpt :Thus, choline has several potential modes of action on the developing fetus. Interestingly, prenatal alcohol may influence methionine absorption [64] and DNA methylation [23], can alter neuronal membrane phospholipid profiles [89] and disrupt cholinergic functioning [14,60,73], although choline does not necessarily need to be influencing the same targets as alcohol to alter the course of physical and behavioral development among alcohol-exposed subjects. Much of what is known of prenatal choline supplementation on brain development is focused on the hippocampus and cortex, areas also known to be adversely affected by prenatal alcohol [7,54].
Adult rat's offspring of alcoholic mothers are impaired on spatial learning and object recognition in the Can test
2006, Behavioural Brain Research
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This study was supported by National Institute on Alcohol Abuse and Alcoholism Grants K21AA00192 (A.H.N.) and AA08696 (R.J.H.) and by a Loyola University Neuroscience and Aging Institute Fellowship (A.H.N.). We thank Jennifer Dowd for her technical assistance.
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Correspondence should be addressed to Alan H. Nagahara, Ph.D., Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80526. Fax: (970) 491-7907.