Regular ArticleBDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia
References (75)
Neurotrophin receptors: A window into neuronal differentiation
Neuron
(1992)- et al.
Akt phosphorylation of BAD couples survival signals to the cell intrinsic death machinery
Cell
(1997) - et al.
Evidence of a novel event during neuronal death—Development of competence-to-die in response to cytoplasmic cytochrome c
Neuron
(1998) - et al.
Differential effects of cAMP in neurons and astrocytes: Role of B-raf
J. Biol. Chem.
(1999) - et al.
Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat
Neurosci. Lett.
(1994) - et al.
Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
Neuron
(1995) - et al.
Differential requirement for caspase 9 in apoptotic pathways in vivo
Cell
(1998) - et al.
DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia–ischemia in the neonatal rat
Brain Res.
(1995) - et al.
p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF
Neuron
(1992) - et al.
The trkB tyrosine kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
Cell
(1990)
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
Cell
Neurotrophins and brain insults
Trends Neurosci.
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
Cell
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
Neuron
Protease activation during apoptosis: Death by a thousand cuts?
Cell
Alteration of BCL-2 family proteins precedes cytoskeletal proteolysis in the penumbra, but not in infarct centres following focal cerebral ischemia in mice
Neuroscience
Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia–ischaemia is related to the degree of high energy phosphate depletion during the insult
Neurosci. Lett.
Increased production of the trkB protein tyrosine kinase receptor after brain insults
Neuron
Enhanced expression of full-length TrkB receptor in young rat brain with hypoxic/ischemic injury
Brain Res.
Caspases: Killer proteases
Trends Biochem. Sci.
Potential new therapies for perinatal cerebral hypoxia–ischemia
Clin. Perinatol.
The oligodendrocyte and its many cellular processes
Trends Cell Biol.
Cold thoughts of death: The role of ICE proteases in neuronal death
Trends Neurosci.
Cytokines and perinatal brain injury
Neurochem. Int.
Functions of the neurotrophins during development: What the knockouts are teaching us
Cell
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
Cell
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Cell
Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system
Neuroscience
Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system
Brain Res.
Intracerebral pretreatment with nerve growth factor prevents irreversible brain lesions in neonatal rats injected with ibotenic acid
Biotechnology
Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion
J. Neurosci.
Regulation of cell death protease caspase-9 by phosphorylation
Science
New insights into the role of oxygen radicals in cerebral ischemia
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
J. Clin. Invest.
Marked age-dependent neuroprotection by BDNF against neonatal hypoxic-ischemic brain injury
Ann. Neurol.
Interleukin-3 induced phosphorylation of BAD through the protein kinase AKT
Science
Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE-family proteases
J. Cell Biol.
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2021, Neurochemistry InternationalCitation Excerpt :Therefore, much attention has been given to finding a safe and effective rehabilitation method for BSCB and understanding its internal molecular mechanism. It has been reported that brain-derived neurotrophic factor (BDNF) provides anti-inflammatory, and anti-neurotoxic effects, promoting neuronal survival and regeneration (Han et al., 2000; Kitagawa, 2007; Bai et al., 2018). BDNF binds to the receptor TrkB, activating multiple intracellular signalling pathways, one of which includes PI3K/AKT/CREB (Hetman et al., 1999; Klocker et al., 2000; Barnabe-Heider and Miller, 2003).
NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis
2019, Genes and DiseasesCitation Excerpt :These findings suggest that NDRG4 may serve as a potential target for IR therapy. Several studies have reported that BDNF mitigates severe ischemia-caused brain injury,14 and also inhibits ischemia-induced neuronal apoptosis via regulation of the expression of Bcl-2, Bax, and Caspase-3.31,32 These reports are consistent with our finding that increased NDRG4 levels in IR rats are linked to greater levels of cortical BDNF and the inhibition of neuronal apoptosis.
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