Statistical analysis
| Code | Data structure | Type of test | 95% CI |
|---|---|---|---|
| a (Fig. 1C) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 108.6 to 272.7, –27.42 to 136.7 and –73.69 to 90.40 |
| b (Fig. 1D) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 51.11 to 98.17 and 11.76 to 58.82 (5dpl); 33.78 to 80.84 and –11.49 to 35.57 (14dpl); 25.89 to 72.95 and –14.29 to 32.77 (21dpl) |
| c (Fig. 1F) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 45.42 to 116.2, 176.9 to 247.7 and 133.9 to 204.7 |
| d (Fig. 1G) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | –2.914 to 37.65 and 60.67 to 101.2 (5dpl); –5.602 to 34.96 and 77.53 to 118.1 (14dpl); –13.63 to 26.93 and 53.74 to 94.30 (21dpl) |
| e (Fig.1I) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | –73.29 to –34.94, –70.07 to –31.72 and –85.01 to –46.66 (low); 19.25 to 57.60, 8.444 to 46.79 and 16.22 to 54.56 (medium); –4.294 to 34.05, 4.099 to 42.45, 11.27 to 49.62 (high) |
| f (Fig. 2B) | Normal distribution, equal variances | Student’s t-test | 201.1 to 231.7 (OLIG2+), 191.3 to 215.4 (CC1+) |
| g (Fig. 2D) | Normal distribution, equal variances | Student’s t-test | 210.2 to 205.7 (OLIG2+), 203.9 to 189.2 (CC1+) |
| h (Fig. 2F) | Normal distribution, equal variances | Student’s t-test | 178.2 to 144.9 (OLIG2+), 165.7 to 136.2 (CC1+) |
| i (Fig.2H) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 70.83 to 72.29 (low); 15.67 to 13.36 (medium); 13.50 to 14.35 (high) |
| j (Fig.2I) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 77.96 to 65.61 (low); 15.85 to 23.22 (medium); 6.186 to 11.17 (high) |
| k (Fig.2J) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 67.91 to 58.45 (low); 21.32 to 31.39 (medium); 10.77 to 10.16 (high) |
| l (Fig. 3B) | Normal distribution, equal variances | Student’s t-test | –307.8 to 246.4 (OLIG2+), –249.9 to 105.2 (CC1+) and –16.51 to 17.07 (CC1+/OLIG2+) |
| m (Fig. 3D) | Normal distribution, equal variances | Student’s t-test | –341.1 to 431.1 (OLIG2+), 13.87 to 270.7 (CC1+) and 2.758 to 17.22 (CC1+/OLIG2+) |
| n (Fig. 3F) | Normal distribution, equal variances | Student’s t-test | –275.5 to 52.4 (OLIG2+), 12.91 to 264.6 (CC1+) and 17.64 to 38.55 (CC1+/OLIG2+) |
| ° (Fig. 3G) | Normal distribution, equal variances | Student’s t-test | 36.15 to 226.8 (DNMT1) and –136.3 to 15.88 (DNMT3A); –134.3 to –21.63 (DNMT1) and 48.69 to 246.2 (DNMT3A); 51.76 to 317.0 (DNMT1) and 106.9 to 307.9 (DNMT3A) |
| p (Fig.4B) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 22.94 to 25.45 (low); 59.72 to 59.83 (medium); 17.33 to 14.72 (high) |
| q (Fig.4D) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 22.71 to 31.26 (low); 58.99 to 55.91 (medium); 18.30 to 12.83 (high) |
| r (Fig.4F) | Normal distribution, equal variances | ANOVA and Bonferroni posttests | 21.26 to 37.88 (low); 61.43 to 49.48 (medium); 17.31 to 12.64 (high) |
| s (Fig. 5B) | Nonnormal distribution | Nonparametric Mann Whitney test | 2.648 to 11.35 and 1.362 to 7.838 |
| t (Fig. 5C) | Normal distribution, unequal variances | Student’s t-test with Welch’s correction | –0.005297 to 0.005700 |
| u (Fig. 5E) | Nonnormal distribution | Nonparametric Mann Whitney test | 1.823 to 11.38 and 2.191 to 9.142 |
| v (Fig. 5F) | Normal distribution, unequal variances | Student’s t-test with Welch’s correction | –0.001182 to 0.01204 |
| x (Fig. 5H) | Nonnormal distribution | Nonparametric Mann Whitney test | –1.006 to 9.256 and 2.886 to 6.864 |
| y (Fig. 5G) | Normal distribution, unequal variances | Student’s t-test with Welch’s correction | –0.01370 to –0.003870 |