Table 3:

Varenicline

TrpB*	EC₅₀ (μM)	n_H	Fold shift	N
Trp	0.0024 ± 0.0001	1.2 ± 0.1	1	15
F₁Trp	0.0057 ± 0.0002	1.2 ± 0.1	2.4	11
F₂Trp	0.0057 ± 0.0021	1.2 ± 0.1	2.4	14
F₃Trp	0.027 ± 0.001	1.3 ± 0.1	11	12
F₄Trp	0.056 ± 0.005	1.1 ± 0.1	23	14

TyrC2	EC₅₀ (μM)	n_H	I_max (μA)	Fold shift	N
Phe	0.0014 ± 0.0002	1.3 ± 0.14	0.04–0.14	1	10
F₁Phe	0.0020 ± 0.00009	1.5 ± 0.09	0.02–0.08	1.4	8
F₂Phe	0.011 ± 0.00097	1.2 ± 0.11	0.02–0.1	8.1	12
F₃Phe	0.027 ± 0.0016	1.1 ± 0.06	0.02–0.09	19	8