Table 3.

Stimulation index–aligned pairwise comparisons (individual drug groups)

p-values (t test)	Core (control) vs. Shell (control)				Core (control) vs. Core (cocaine)				Shell (control) vs. Shell (cocaine)
Stimulation index	100	300	600	1200	100	300	600	1200	100	300	600	1200
Peak [DA]	0.002*	0.96	0.02	0.48	<0.0001*	0.003*	0.0006*	0.009*	0.02	0.96	0.99	0.14
Frequency	0.97	0.002*	0.46	1.00	0.24	0.73	0.87	0.14	0.12	0.37	0.76	1.00
AUC	0.01	0.98	0.21	0.45	0.0006*	0.003*	0.002*	0.02	0.06	0.70	0.83	0.14
Rise velocity	0.0006*	0.006*	0.0003*	<0.0001*	0.0002*	0.0002*	0.006*	0.0006*	0.31	0.42	0.49	0.14
Latency peak	0.002*	<0.0001*	<0.0001*	<0.0001*	0.45	0.36	0.61	0.11	0.07	0.002*	0.005*	0.01
V_max	0.002*	0.003*	<0.0001*	0.0003*	0.001*	0.001*	0.0002*	0.004*	0.01*	0.78	0.78	0.16
FWHH	<0.0001*	<0.0001*	<0.0001*	<0.0001*	0.15	0.52	0.59	0.09	0.89	0.05	0.003*	0.13
Slope (T20–T80)	0.001*	0.81	0.004*	0.26	0.009*	0.03	0.002*	0.09	0.004*	0.77	0.68	0.10
Baseline return	0.26	0.74	0.96	0.91	0.07	0.01	0.11	0.03	0.56	0.28	0.10	0.88
T20 latency	<0.0001*	<0.0001*	<0.0001*	<0.0001*	0.02	0.32	0.09	0.07	0.30	0.10	0.28	0.31
T80 latency	0.006*	0.25	0.02	0.0004*	0.53	0.06	0.56	0.09	0.21	0.72	0.66	0.18

Significance (p-value) of pairwise t tests at each stimulation index bin (low [100–300], medium-low [300–600], medium-high [600–1200], and high [>1200]) between core control and shell control (left), core control and core cocaine (middle), and shell control and shell cocaine (right). Bold italics: *p < 0.01 (significant after Bonferroni correction); italics only: p < 0.05 (not significant after Bonferroni correction).