β2*-nAChR interacting proteins identified by iTRAQ analysis of receptors isolated from transgenic mouse cortex receiving long-term treatment with nicotine and not receiving nicotine treatment (GN, gene name)
| Accession | Description | Correlation (r) | p Value |
|---|---|---|---|
| sp|O70174|ACHA4_MOUSE | Neuronal acetylcholine receptor subunit α4 OS = Mus musculus GN = Chrna4 PE = 2 SV = 2 | 0.97 | <0.0009 |
| sp|Q2MKA5|ACHA5_MOUSE | Neuronal acetylcholine receptor subunit α5 OS = Mus musculus GN = Chrna5 PE = 2 SV = 1 | 0.91 | <0.0009 |
| sp|Q9ERK7|ACHB2_MOUSE | Neuronal acetylcholine receptor subunit β2 OS = Mus musculus GN = Chrnb2 PE = 2 SV = 1 | 1 | <0.0009 |
| sp|Q6PIC6|AT1A3_MOUSE | Sodium/potassium-transporting ATPase subunit α3 OS = Mus musculus GN = Atp1a3 PE = 1 SV = 1 | 0.55 | 0.042 |
| sp|Q62277|SYPH_MOUSE | Synaptophysin OS = Mus musculus GN = Syp PE = 1 SV = 2 | 0.59 | 0.026 |
Similar to the results from human cortex samples, presynaptic elements related to vesicle fusion (synaptophysin) and neuronal excitability (ATP1A3) are significantly correlated with nAChR levels.