@article {GunerENEURO.0255-16.2017, author = {Gokhan Guner and Gizem Guzelsoy and Fatma Sadife Isleyen and Gulcan Semra Sahin and Cansu Akkaya and Efil Bayam and Eser Ilgin Kotan and Alkan Kabakcioglu and Gulayse Ince-Dunn}, title = {NEUROD2 Regulates Stim1 Expression and Store-Operated Calcium Entry in Cortical Neurons}, volume = {4}, number = {1}, elocation-id = {ENEURO.0255-16.2017}, year = {2017}, doi = {10.1523/ENEURO.0255-16.2017}, publisher = {Society for Neuroscience}, abstract = {Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development.}, URL = {https://www.eneuro.org/content/4/1/ENEURO.0255-16.2017}, eprint = {https://www.eneuro.org/content/4/1/ENEURO.0255-16.2017.full.pdf}, journal = {eNeuro} }