RT Journal Article SR Electronic T1 Computational Architecture of the Parieto-Frontal Network Underlying Cognitive-Motor Control in Monkeys JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0306-16.2017 DO 10.1523/ENEURO.0306-16.2017 VO 4 IS 1 A1 Roberto Caminiti A1 Elena Borra A1 Federica Visco-Comandini A1 Alexandra Battaglia-Mayer A1 Bruno B. Averbeck A1 Giuseppe Luppino YR 2017 UL http://www.eneuro.org/content/4/1/ENEURO.0306-16.2017.abstract AB The statistical structure of intrinsic parietal and parieto-frontal connectivity in monkeys was studied through hierarchical cluster analysis. Based on their inputs, parietal and frontal areas were grouped into different clusters, including a variable number of areas that in most instances occupied contiguous architectonic fields. Connectivity tended to be stronger locally: that is, within areas of the same cluster. Distant frontal and parietal areas were targeted through connections that in most instances were reciprocal and often of different strength. These connections linked parietal and frontal clusters formed by areas sharing basic functional properties. This led to five different medio-laterally oriented pillar domains spanning the entire extent of the parieto-frontal system, in the posterior parietal, anterior parietal, cingulate, frontal, and prefrontal cortex. Different information processing streams could be identified thanks to inter-domain connectivity. These streams encode fast hand reaching and its control, complex visuomotor action spaces, hand grasping, action/intention recognition, oculomotor intention and visual attention, behavioral goals and strategies, and reward and decision value outcome. Most of these streams converge on the cingulate domain, the main hub of the system. All of them are embedded within a larger eye–hand coordination network, from which they can be selectively set in motion by task demands.