@article {Catuara-SolarzENEURO.0103-16.2016, author = {Silvina Catuara-Solarz and Jose Espinosa-Carrasco and Ionas Erb and Klaus Langohr and Juan Ramon Gonzalez and Cedric Notredame and Mara Dierssen}, title = {Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome}, volume = {3}, number = {5}, elocation-id = {ENEURO.0103-16.2016}, year = {2016}, doi = {10.1523/ENEURO.0103-16.2016}, publisher = {Society for Neuroscience}, abstract = {Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.}, URL = {https://www.eneuro.org/content/3/5/ENEURO.0103-16.2016}, eprint = {https://www.eneuro.org/content/3/5/ENEURO.0103-16.2016.full.pdf}, journal = {eNeuro} }