TY - JOUR T1 - Involvement of CRFR<sub>1</sub> in the Basolateral Amygdala in the Immediate Fear Extinction Deficit JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0084-16.2016 VL - 3 IS - 5 SP - ENEURO.0084-16.2016 AU - Fiona Hollis AU - Yannick Sevelinges AU - Jocelyn Grosse AU - Olivia Zanoletti AU - Carmen Sandi Y1 - 2016/09/01 UR - http://www.eneuro.org/content/3/5/ENEURO.0084-16.2016.abstract N2 - Several animal and clinical studies have highlighted the ineffectiveness of fear extinction sessions delivered shortly after trauma exposure. This phenomenon, termed the immediate extinction deficit, refers to situations in which extinction programs applied shortly after fear conditioning may result in the reduction of fear behaviors (in rodents, frequently measured as freezing responses to the conditioned cue) during extinction training, but failure to consolidate this reduction in the long term. The molecular mechanisms driving this immediate extinction resistance remain unclear. Here we present evidence for the involvement of the corticotropin releasing factor (CRF) system in the basolateral amygdala (BLA) in male Wistar rats. Intra-BLA microinfusion of the CRFR1 antagonist NBI30775 enhances extinction recall, whereas administration of the CRF agonist CRF6–33 before delayed extinction disrupts recall of extinction. We link the immediate fear extinction deficit with dephosphorylation of GluA1 glutamate receptors at Ser845 and enhanced activity of the protein phosphatase calcineurin in the BLA. Their reversal after treatment with the CRFR1 antagonist indicates their dependence on CRFR1 actions. These findings can have important implications for the improvement of therapeutic approaches to trauma, as well as furthering our understanding of the neurobiological mechanisms underlying fear-related disorders. ER -