Review, Novel Tools and Methods
Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury
Tanchen Ren, Yolandi van der Merwe and Michael B. Steketee
eNeuro 18 September 2015, 2 (5) ENEURO.0077-15.2015; DOI: https://doi.org/10.1523/ENEURO.0077-15.2015
Tanchen Ren
1Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15216
2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219
Yolandi van der Merwe
1Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15216
2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219
3Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Michael B. Steketee
1Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15216
2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219
4Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15216
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Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury
Tanchen Ren, Yolandi van der Merwe, Michael B. Steketee
eNeuro 18 September 2015, 2 (5) ENEURO.0077-15.2015; DOI: 10.1523/ENEURO.0077-15.2015
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- Article
- Abstract
- Significance Statement
- Introduction
- The innate immune response and CNS regeneration
- Extracellular matrix technology
- Modulating inflammation is critical to a positive outcome in CNS tissues like retina and optic nerve
- ECM technology can mitigate secondary trauma
- ECM hydrogels are a highly tunable biologic platform
- ECM hydrogels
- ECM biohybrid bioscaffolds
- ECM hydrogels for cellular transplantation
- Non-tissue-specific ECMs can also promote positive CNS repair
- Conclusion
- Acknowledgments
- Footnotes
- References
- Synthesis
- Figures & Data
- Info & Metrics
- eLetters
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