- research article | New Research, Neuronal Excitability Neuron Morphology Influences Axon Initial Segment Plasticity
In most vertebrate neurons, action potentials are initiated in the axon initial segment (AIS), a specialized region of the axon containing a high density of voltage-gated sodium and potassium channels.
Published January 18, 2016
- research article | New Research, Neuronal Excitability Climbing Fiber Regulation of Spontaneous Purkinje Cell Activity and Cerebellum-Dependent Blink Responses
Published January 5, 2016
- research article | New Research, Neuronal Excitability Depolarization of Hippocampal Neurons Induces Formation of Nonsynaptic NMDA Receptor Islands Resembling Nascent Postsynaptic Densities
Published November 18, 2015
- research article | New Research, Neuronal Excitability Mechanisms Leading to Rhythm Cessation in the Respiratory PreBötzinger Complex Due to Piecewise Cumulative Neuronal Deletions
Published August 18, 2015
- research article | New Research, Neuronal Excitability Metaplastic Regulation of CA1 Schaffer Collateral Pathway Plasticity by Hebbian MGluR1a-Mediated Plasticity at Excitatory Synapses onto Somatostatin-Expressing Interneurons
Published August 12, 2015
- research article | New Research, Neuronal Excitability Variability in State-Dependent Plasticity of Intrinsic Properties during Cell-Autonomous Self-Regulation of Calcium Homeostasis in Hippocampal Model Neurons
Published August 11, 2015
- research article | New Research, Neuronal Excitability Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3
Published July 15, 2015
- research article | New Research, Neuronal Excitability Leptin Induces a Novel Form of NMDA Receptor-Dependent LTP at Hippocampal Temporoammonic-CA1 Synapses
Hippocampal CA1 pyramidal neurons receive two anatomically distinct glutamatergic inputs that have distinct roles in learning and memory. The hormone leptin markedly influences excitatory synaptic transmission at the indirect Schaffer-collateral pathway to CA1 neurons.
Published May 26, 2015
- research article | New Research, Neuronal Excitability PKA and cAMP/CNG Channels Independently Regulate the Cholinergic Ca2+-Response of Drosophila Mushroom Body Neurons
The mushroom bodies (MBs) are the most prominent structures in adult Drosophila brain. They have been involved in several crucial functions, such as learning and memory, sleep, locomotor activity, and decision making.
Published April 17, 2015
- research article | New Research, Neuronal Excitability Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses
Endocannabinoids and neurotrophins, particularly brain-derived neurotrophic factor (BDNF), are potent neuromodulators that play critical roles in many behavioral and physiological processes. Disruption of either BDNF or endocannabinoid signaling is associated with an overlapping set of neurologic and psychiatric diseases, and both systems are currently major targets for the development of novel therapeutics, particularly in relation to depression, anxiety, autism, and schizophrenia.
Published March 24, 2015