- research article | New Research, Neuronal Excitability A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression
The regulation of neuronal gene expression requires dynamic changes in chromatin structure as evidenced by the fact that dysregulation of the enzymes responsible for chromatin modification often leads to intellectual disability. In this article, we characterize a chromatin-modifying complex containing the X-linked mental retardation-associated protein PHF8 and the Alzheimer’s disease-associated protein TIP60, which regulates the expression of an important neuronal activity-dependent gene, Arc.
Published January 27, 2015
- research article | Failure to Replicate, Neuronal Excitability Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron CaV Current
Better analgesic drugs are desperately needed to help physicians to treat pain. While many preclinical studies support the analgesic effects of α-conopeptides, Vc1.1 and RgIA, the mechanism is controversial.
Published January 16, 2015
- research article | New Research, Neuronal Excitability Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation
This manuscript reports a novel epigenetic role for the neuronal immediate early gene Arc, a master regulator of synaptic plasticity and critical effector of memory consolidation. Arc protein is localized both to synapses, where its role is well studied, and to the nucleus, where its function is still obscure.
Published November 12, 2014