- research article | New Research, Neuronal Excitability What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro?
The inflammatory and central nervous systems share many signaling molecules, compromising the utility of traditional pharmacological and knockout approaches in defining the role of inflammation in CNS disorders such as epilepsy. In an in vitro model of post-traumatic epileptogenesis, the development of epilepsy proceeded in the absence of the systemic inflammatory system, and was unaffected by removal of cellular mediators of inflammation, including macrophages and T-lymphocytes.
Published March 3, 2015
- research article | New Research, Neuronal Excitability Presynaptic NR2A-Containing NMDARs Are Required for LTD between the Amygdala and the Perirhinal Cortex: A Potential Mechanism for the Emotional Modulation of Memory?
Emotional events are better remembered than emotionally neutral events. The ability of memory enhancement by emotion is dependent on amygdala-mediated alterations of synaptic activity.
Published February 25, 2015
- research article | New Research, Neuronal Excitability Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms
Neurons expressing the neuropeptide hypocretin regulate many behavioral functions, including sleep, motivation, and behaviors related to addiction. The ability of nicotine to stimulate nicotinic acetylcholine receptors (nAChRs) is essential for its addictive properties, but little is known about whether, and how, nicotine and the endogenous neurotransmitter acetylcholine affect hypocretin neurons.
Published February 18, 2015
- research article | New Research, Neuronal Excitability Dynamic Input Conductances Shape Neuronal Spiking
Reliable neuron activity is ensured by a tight regulation of the ion channels that resides in the neuron’s membrane. Understanding the causal mechanisms that relate this regulation to physiological and pathological neuronal activity is a necessary step for developing efficient therapies for neurological diseases associated with abnormal nervous system activity.
Published February 18, 2015
- research article | New Research, Neuronal Excitability A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression
The regulation of neuronal gene expression requires dynamic changes in chromatin structure as evidenced by the fact that dysregulation of the enzymes responsible for chromatin modification often leads to intellectual disability. In this article, we characterize a chromatin-modifying complex containing the X-linked mental retardation-associated protein PHF8 and the Alzheimer’s disease-associated protein TIP60, which regulates the expression of an important neuronal activity-dependent gene, Arc.
Published January 27, 2015
- research article | Failure to Replicate, Neuronal Excitability Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron CaV Current
Better analgesic drugs are desperately needed to help physicians to treat pain. While many preclinical studies support the analgesic effects of α-conopeptides, Vc1.1 and RgIA, the mechanism is controversial.
Published January 16, 2015
- research article | New Research, Neuronal Excitability Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation
This manuscript reports a novel epigenetic role for the neuronal immediate early gene Arc, a master regulator of synaptic plasticity and critical effector of memory consolidation. Arc protein is localized both to synapses, where its role is well studied, and to the nucleus, where its function is still obscure.
Published November 12, 2014