- research article | Negative Results, Disorders of the Nervous System Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice
Published June 22, 2015
- research article | Negative Results, Disorders of the Nervous System Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease
Despite numerous reports indicating HIF-1α expression in glia, neurons, and inflammatory cells in the CNS of MS patients, the cell-specific contribution of HIF-1α to disease pathogenesis remains unclear. Here we show that although HIF-1α is dramatically upregulated in astrocytes and myeloid cells in EAE, cell-specific depletion of HIF-1α in these two cell types surprisingly does not affect the development of neuroinflammatory disease.
Published March 30, 2015
- research article | Negative Results, Disorders of the Nervous System The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice
Parkinson’s disease research has been hampered by the absence of animal models that replicate the disease phenotypes observed in humans. We hypothesized that the reason mice lacking DJ-1, a gene that causes parkinsonism when mutated, do not replicate the human phenotype is because mice do not have the same levels of mtDNA damage that humans do.
Published February 24, 2015
- research article | Disorders of the Nervous System, Negative Results Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion
TRPM2 is an ion channel that is activated by ischemia in stroke and contributes to neuronal injury only in males. We tested whether the lack of TRPM2 activation following stroke in females is caused by differences in sex steroids.
Published November 12, 2014